Due to their rare combination of high chemical stability, exceptional optical and electrical properties, high surface-to-volume ratio, and high aspect ratio, carbon nanotubes (CNTs) have made an enormous impact on materials science, molecular biology, biomedicine, and bioanalytical chemistry. Carbon Nanotubes: Methods and Protocols provides reliable, consistent protocols on the application of CNTs in molecular biology-related fields. These are of vital importance, as the commercially available CNTs differ in purity, agglomeration state, as well as length and diameter distribution, all of which have a profound influence on the dispersability and surface properties of the tubes. The volume contains detailed sections on functionalization, toxicity, trafficking, scaffolds, and biosensors, provided by expert researchers from various fields. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Carbon Nanotubes: Methods and Protocols serves to contribute to the achievement of common standards and helps researchers to avoid discrepancies in future biology-related CNT studies.
Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular Biology™ series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.
Containing contributions from an international team of opinion leaders, this new book reviews the key advances in equipment, techniques and therapeutics and is an accessible reference for all hospital-based specialists.
Representing nearly fifty years of cooperation between Wiley and the Structural Stability Research Council, the Guide to Stability Design Criteria for Metal Structures is often described as an invaluable reference for practicing structural engineers and researchers. For generations of engineers and architects, the Guide has served as the definitive work on designing steel and aluminum structures for stability. Under the editorship of Ronald Ziemian and written by SSRC task group members who are leading experts in structural stability theory and research, this Sixth Edition brings this foundational work in line with current practice and research.
The Sixth Edition incorporates a decade of progress in the field since the previous edition, with new features including:
Updated chapters on beams, beam-columns, bracing, plates, box girders, and curved girders. Significantly revised chapters on columns, plates, composite columns and structural systems, frame stability, and arches
Fully rewritten chapters on thin-walled (cold-formed) metal structural members, stability under seismic loading, and stability analysis by finite element methods
State-of-the-art coverage of many topics such as shear walls, concrete filled tubes, direct strength member design method, behavior of arches, direct analysis method, structural integrity and disproportionate collapse resistance, and inelastic seismic performance and design recommendations for various moment-resistant and braced steel frames
Complete with over 350 illustrations, plus references and technical memoranda, the Guide to Stability Design Criteria for Metal Structures, Sixth Edition offers detailed guidance and background on design specifications, codes, and standards worldwide.
Topics covered include the classification of mental disorders in intellectual disability, the clinical assessment of specific disorders, psychological, psychopharmacological and social interventions, and the practical, legal, and social aspects of supporting service users with intellectual disability who have mental health problems.
The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs.
For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates.
Key features:
Back-to-basics gardening that will benefit the earth and your wallet!
Want to use ordinary waste to create an extraordinary garden? Composting lets you turn household food waste, yard clippings, and more into free compost and mulch that's chock-full of nutrients. From building and working with traditional compost bins to starting an indoor worm-composting operation, Composting For Dummies makes these often intimidating projects easy, fun, and accessible for anyone!
Digging into compost basics — get a handle on the benefits of composting and the tools you'll need to get started
Choosing the best method and location — find the best composting method and location that's right for you, whether it's above ground, in a hole, in a container or bin, or even right in your kitchen
Building your pile — learn which ingredients can go into your compost pile, what stays out, and how to mix it all up in the right proportions
Stepping beyond traditional composting — get the lowdown on vermicomposting (letting worms eat your garbage), growing green manures to compost later, and sheet composting in the same spot you plan to plant
Open the book and find:
A step-by-step guide to composting
The right gear and tools for the job
Tips on constructing your own composting containers and bins
Materials you can safely compost (and those to avoid)
Cover crops to improve your soil now and compost later
Recommendations for using your finished compost
What worms contribute to your compost
Troubleshooting advice if your compost pile isn't cooperating
Learn to:
Turn household food waste, yard clippings, and more into nutrient-rich compost
Build and maintain your own compost bin
Use worms to aid in composting, both indoors and out
Give your vegetable and flower gardens a boost of energy
A comprehensive reference for the poultry industry—Volume 1 describes everything from husbandry up to preservation
With an unparalleled level of coverage, the Handbook of Poultry Science and Technology provides an up-to-date and comprehensive reference on poultry processing. Volume 1 describes husbandry, slaughter, preservation, and safety. It presents all the details professionals need to know beginning with live poultry through to the freezing of whole poultry and predetermined cut parts. Throughout, the coverage focuses on one paramount objective: an acceptable quality and a safe product for consumer purchase and use. The text includes safety requirements and regulatory enforcement in the United States, EU, and Asia.
Volume 1: Primary Processing is divided into seven parts:
Poultry: biology to pre-mortem status—includes such topics as classification and biology, competitive exclusion, transportation to the slaughterhouse, and more
Slaughtering and cutting—includes the slaughterhouse building and required facilities, equipment, and operations; carcass evaluation and cutting; kosher and halal slaughter; and more
Preservation: refrigeration and freezing—includes the biology and physicochemistry of poultry meat in rigor mortis under ambient temperature, as well as changes that occur during freezing and thawing; engineering principles; equipment and processes; quality; refrigeration and freezing for various facilities; and more
Preservation: heating, drying, chemicals, and irradiation
Composition, chemistry, and sensory attributes—includes quality characteristics, microbiology, nutritional components, chemical composition, and texture of raw poultry meat
Eggs—includes egg attributes, science, and technology
Sanitation and Safety—includes PSE, poultry-related foodborne diseases, OSHA requirements, HACCP and its application, and more
A comprehensive reference for the poultry industry
—Volume 2 describes poultry processing from raw meat to final retail products
With an unparalleled level of coverage, the Handbook of Poultry Science and Technology provides an up-to-date and comprehensive reference on poultry processing. Volume 2: Secondary Processing covers processing poultry from raw meat to uncooked, cooked or semi-cooked retail products. It includes the scientific, technical, and engineering principles of poultry processing, methods and product categories, product manufacturing and attributes, and sanitation and safety.
Volume 2: Secondary Processing is divided into seven parts:
Secondary processing of poultry products—an overview
Methods in processing poultry products—includes emulsions and gelations; breading and battering; mechanical deboning; marination, cooking, and curing; and non-meat ingredients
Product manufacturing—includes canned poultry meat, turkey bacon and sausage, breaded product (nuggets), paste product (paté), poultry ham, luncheon meat, processed functional egg products, and special dietary products for the elderly, the ill, children, and infants
Product quality and sensory attributes—includes texture and tenderness, protein and poultry meat quality, flavors, color, handling refrigerated poultry, and more
Engineering principles, operations, and equipment—includes processing equipment, thermal processing, packaging, and more
Contaminants, pathogens, analysis, and quality assurance—includes microbial ecology and spoilage in poultry and poultry products; campylobacter; microbiology of ready-to-eat poultry products; and chemical and microbial analysis
Safety systems in the United States—includes U.S. sanitation requirements, HACCP, U.S. enforcement tools and mechanisms
Molecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists’ and students’ understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.
Jeannine Yon-Kahn, Emeritus Director of Research at the CNRS, created and directed the Laboratory of Physicochemical Enzymology at the University of Paris-Sud (Orsay, France). She was Director of Doctoral Studies in the Structure, Function and Engineering of Proteins. She was a member of several Scientific Committees (including CNRS and INRA) and is a foreign member of the Brazilian Academy of Sciences.
Guy Hervé, Emeritus Director of Research at the CNRS, was Director of the CNRS Institute of Enzymology and of one of the Biochemistry Laboratories at the Pierre and Marie Curie University in Paris. He was also Director of the Doctoral School of Molecular and Cellular Biology at that same university and President of the French Biophysical Society.
The manned mission is seen as a first step towards a Mars surface exploration base-station and, later, establishing permanent settlement. The location and use of Mars’s natural resources is vital to enable cost-effective long-duration human exploration and exploitation missions as well as subsequent human colonization. Planet resources include various crust-lodged materials, a low-pressure natural atmosphere, assorted forms of utilizable energy, lower gravity than Earth’s, and ground placement advantages relative to human operability and living standards. Power resources may include using solar and wind energy, importation of nuclear reactors and the harvesting of geothermal potential.
In fact, a new branch of human civilization could be established permanently on Mars in the next century. But, meantime, an inventory and proper social assessment of Mars’s prospective energy and material resources is required. This book investigates the possibilities and limitations of various systems supplying manned bases on Mars with energy and other vital resources. The book collects together recent proposals and innovative options and solutions. It is a useful source of condensed information for specialists involved in current and impending Mars-related activities and a good starting point for young researchers.
The campstead is an American institution. After the Civil War, with neo-colonialism, environmentalism, and arts-and-crafts on the rise, some families sought rural locations for rustic camps. There they raised their children in the summertime. Around Squam Lake, after some eight generations, twenty-one such camps remain in these families.
The Squam area thus becomes a natural place to study relationships of persons and places, families and landscape, and humans and the world. Our present concerns for environmental stewardship, open space protection, and core values instead of consumerism, make this a good time to revisit the simple American Campstead.
Rustic camping itself revisited aspects of the American frontier. Just as the western frontier was disappearing, some families resorted to remnants of the first frontier among mountains and lakes of the Northeast. Through campsteads, these families preserved elements of the frontier ethos. Campsteads facilitate particular experiences involving nature and family. Brereton investigates campstead experience, and through it the nature of human experience generally.
This book is the first detailed account of campsteading, the first application of critical realism in anthropology, and the first anthropological use of John Dewey's evolutionary model of experience. Building on Dewey, the author further analyses experience into its levels, orders, and features.
The multidisciplinary approach in evaluating the history of Amazonia has resulted in a comprehensive volume that provides novel insights into the evolution of this region. The book is written by leading scientists of the Amazonian research community and can serve as reference to all scientists working in Amazonia. However, it should be of particular interest to students and researchers concerned with the natural history of Amazonia. Potential readers will include geologists, geographers and biologists who wish to understand the evolution of landscapes and biota of this unique region.
Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems
Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology.
Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology
Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine
Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems
Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology
Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.
The first advanced-level
genetics counseling skills resource
As genetic medicine and testing continue to expand, so the role of the genetic counselor is transforming and evolving. Genetic Counseling Practice: Advanced Concepts and Skills is the first text to address ways that genetic counselors can deepen their skills to meet expanding practice demands. This timely resource not only helps readers further develop their abilities to gather relevant data and interpret it for patients, it also aids them in surpassing their usual role by truly understanding patient situations, incorporating patient values into clinical practice, providing in-depth support, and facilitating thoroughly informed, autonomous decisions.
Edited by an expert cross-disciplinary team consisting of a genetic counseling program director, a licensed psychologist, and a nurse/bioethicist/family social scientist, this authoritative reference provides specific and detailed instruction in addressing psychosocial aspects of genetic counseling practice and professional development and training issues of genetic counselors.
Provides a process view of genetic counselor service provision; i.e., skills that promote desired genetic counseling outcomes are emphasized (such as relationship skills, patient characteristics, client behaviors, and extra-clinical skills)
Includes experiential activities in every chapter to help readers apply concepts and skills
Draws on the experience of widely recognized experts in genetic counseling theory, practice, and research, who serve as chapter authors
Features numerous specific, real-life examples from clinical practice
Genetic Counseling Practice addresses issues relevant to practicing genetic counselors as well as students of genetic counseling programs. In addition, oncology nurses, social workers, and psychologists working with genetic counseling patients and families; medical geneticists and physicians training in the field; and physician assistants will also benefit from this resource.
Completely revised and updated to incorporate the latest data in the field,Lewin's CELLS, Second Editionis the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.
The SARS outbreak in 2002 caused unprecedented devastation and exhibited unusually high rates of morbidity and mortality. For the SARS coronavirus, the transmission vehicle was man. What added to the spread was man’s convenient, rapid and affordable ways of travel that caused the virus to spread globally in a short span of time. The SARS coronavirus jumped the species barrier, similar to many recent zoonotic diseases – avian flu, swine flu, Nipah and encephalitis virus. It is extremely important for us to understand the enemy before it strikes again in order to be able to combat such outbreaks as and when they occur. Molecular mechanisms that the virus exploits within its host and that result in infection and pathogenesis are the key to being able to block its transmission cycle. In this book, leading scientists from around the globe have discussed molecular aspects of viral entry, replication, viral gene expression, pathogenesis and host immune response against the SARS coronavirus.
Covers the most advanced computational and experimental methods for studying carbon-centered radical intermediates
With its focus on the chemistry of carbon-centered radicals and radical cations, this book helps readers fully exploit the synthetic utility of these intermediates in order to prepare fine chemicals and pharmaceutical products. Moreover, it helps readers better understand their role in complex atmospheric reactions and biological systems. Thoroughly up to date, the book highlights the most advanced computational and experimental methods available for studying and using these critically important intermediates.
Carbon-Centered Free Radicals and Radical Cations begins with a short history of the field of free radical chemistry, and then covers:
A discussion of the relevant theory
Mechanistic chemistry, with an emphasis on synthetic utility
Molecular structure and mechanism, focusing on computational methods
Spectroscopic investigations of radical structure and kinetics, including demonstrations of spin chemistry techniques such as CIDNP and magnetic field effects
Free radical chemistry in macromolecules
Each chapter, written by one or more leading experts, explains difficult concepts clearly and concisely, with references to facilitate further investigation of individual topics. The authors were selected in order to provide insight into a broad range of topics, including small molecule synthesis, polymer degradation, computational chemistry as well as highly detailed experimental work in the solid, liquid, and gaseous states.
This volume is essential for students or researchers interested in building their understanding of the role of carbon-centered radical intermediates in complex systems and how they may be used to develop a broad range of useful products.
About the Contents:
Pretest
Helps you pinpoint where you need the most help
Topic Area Reviews
Measurement and Units of Measurement
Matter: Elements, Compounds, and Mixtures
Atoms I—The Basics
Formulas and Names of Ionic Compounds, Acids, and Bases
The Mole—Elements and Compounds
Percent Composition and Empirical and Molecular Formulas
Chemical Reactions and Chemical Equations
Calculations Using Balanced Equations
Atoms II—Atomic Structure and Periodic Properties
Chemical Bonding—The Formation of Compounds
Gases and the Gas Laws
The Forces between Molecules—Solids and Liquids
Solutions and Solution Composition
Acids, Bases, and Neutralization
Glossary
Customized Full-Length Exam Covers all subject areas
Pretest that pinpoints what you need to study most
Clear, concise reviews of every topic
Targeted example problems in every chapter with solutions and explanations
Customized full-length exam that adapts to your skill level
Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.
The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.
Fully updated and expanded to reflect important 21
st century advances, the fifth edition of this classic text includes the following innovations:Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.
Wiley and NIST have recently added hundreds of thousands of compounds to their mass spectral libraries. If your spectral libraries are out of date, chances are higher that your lab won't be able detect the broad array of compounds featured in the latest libraries. Upgrade your library today to ensure that your laboratory can offer the broadest detection commercially available.
Does My Lab Qualify for an Upgrade?
If your lab has a valid license to any previous edition of the Wiley Registry and any previous edition of the NIST/EPA/NIH, your lab qualifies to upgrade to the combined Wiley Registry 9th/NIST 2008.
Ensure Your Lab Has the Most Comprehensive Library
Wiley combined the two most trusted names in mass spectrometry into one easy-to-manage package with the Wiley Registry ® 9th Edition/NIST 2008. Each DVD contains the complete deduplicated Wiley Registry/NIST library and the complete NIST/EPA/NIH library and software installation. The mass spectral libraries are bundled in most common software formats - taking the guesswork out of compatibility.
The deduplicated Wiley/NIST library contains over 796,000 mass spectra, covering 667,000 compounds, with 746,000 spectra with searchable chemical structures - making it the largest, most comprehensive combined library ever.
Also included on the DVD is the complete NIST/EPA/NIH 2008 library, including a new release of NIST MS Search software with AMDIS. The new release of NIST MS Search greatly expands available memory for library searches and improves memory handling and search performance.
What's Included
Each DVD contains:
Complete Wiley Registry 9th/NIST 2008 library:
Complete NIST/EPA/NIH 2008 with MS Search
Multiple Formats for Easy Installation
Wiley takes the guesswork out of installation by bundling multiple manufacturer-native formats of the libraries on each DVD and providing a simple Web-browser installation screen. Each library has been tested and optimized to run on the current versions of most manufacturer's software.
Below are the formats available on each DVD:
Wiley Registry 9th/NIST 2008:
NIST/EPA/NIH 2008:
System Requirements
Wiley combined the two most trusted names in mass spectrometry into one easy-to-manage package with the Wiley Registry ® 9th Edition/NIST 2008. Each DVD contains the complete deduplicated Wiley Registry/NIST library and the complete NIST/EPA/NIH library and software installation. The mass spectral libraries are bundled in most common software formats - taking the guesswork out of compatibility.
The deduplicated Wiley/NIST library contains over 796,000 mass spectra, covering 667,000 compounds, with 746,000 spectra with searchable chemical structures - making it the largest, most comprehensive combined library ever.
Also included on the DVD is the complete NIST/EPA/NIH 2008 library, including a new release of NIST MS Search software with AMDIS. The new release of NIST MS Search greatly expands available memory for library searches and improves memory handling and search performance.
What's Included
Each DVD contains:
Complete Wiley Registry 9th/NIST 2008 library:
Complete NIST/EPA/NIH 2008 with MS Search
Multiple Formats for Easy Installation
Wiley takes the guesswork out of installation by bundling multiple manufacturer-native formats of the libraries on each DVD and providing a simple Web-browser installation screen. Each library has been tested and optimized to run on the current versions of most manufacturer's software.
Below are the formats available on each DVD:
Wiley Registry 9th/NIST 2008:
NIST/EPA/NIH 2008:
System Requirements
Mylonites form in response to high rates of strain within deep ductile shear zones, which are the extensions at depth of surface faults, thrusts and fault breccias, They can have many different mineralogical compositions and are therefore defined on their textural appearance. This atlas provides high definition images of a large number of different mylonites allowing students and geologists to correctly classify them with greater ease. It also provides insights into the interpretation of mylonitic fabrics to answer questions such as; from what type of rock did this mylonite derive? What were the metamorphic circumstances during mylonitization? What was the intensity of deformation?, and What was the sense of shear?
This book will complement the very successful textbook "Microtectonics" by Passchier and Trouw.
A Definitive text on developing circuit simulators
Circuit Simulation gives a clear description of the numerical techniques and algorithms that are part of modern circuit simulators, with a focus on the most commonly used simulation modes: DC analysis and transient analysis. Tested in a graduate course on circuit simulation at the University of Toronto, this unique text provides the reader with sufficient detail and mathematical rigor to write his/her own basic circuit simulator. There is detailed coverage throughout of the mathematical and numerical techniques that are the basis for the various simulation topics, which facilitates a complete understanding of practical simulation techniques. In addition, Circuit Simulation:
Explores a number of modern techniques from numerical analysis that are not synthesized anywhere else
Covers network equation formulation in detail, with an emphasis on modified nodal analysis
Gives a comprehensive treatment of the most relevant aspects of linear and nonlinear system solution techniques
States all theorems without proof in order to maintain the focus on the end-goal of providing coverage of practical simulation methods
Provides ample references for further study
Enables newcomers to circuit simulation to understand the material in a concrete and holistic manner
With problem sets and computer projects at the end of every chapter, Circuit Simulation is ideally suited for a graduate course on this topic. It is also a practical reference for design engineers and computer-aided design practitioners, as well as researchers and developers in both industry and academia.
About the Contents:
Pretest
Helps you pinpoint where you need the most help and directs you to the corresponding sections of the book
Topic Area Reviews
Math Basics
Numbers (Signed Numbers and Fractions)
Linear Equations and Algebraic Fractions
Polynomials and Factoring
Inequalities, Absolute Value Inequalities, and Radicals
Introducing Quadratic Equations—Testing Solutions
Graphing and Systems of Equations
Functions
Story Problems
Customized Full-Length Exam
Covers all subject areas
Pretest that pinpoints what you need to study most
Clear, concise reviews of every topic
Targeted example problems in every chapter with solutions and explanations
Customized full-length exam that adapts to your skill level
Requirements Engineering for Computer Integrated Environments in Construction provides an important source of information and advice for organizations needing bridge the gap between users and developers in the implementation of computer integrated solutions as well as for consultants providing services to their clients in CIE development.
The framework explained in the book is comprehensive and accessible. It provides a set of tools and techniques enabling readers to design, manage and deliver effective CIE-type systems in any complex organization – from construction and manufacturing to the information technology and service sectors. Construction companies for example, can use the framework provided to implement building information modelling to manage the diagnosis, planning, implementation and monitoring stages in BIM adoption.
Based on real experiences and lessons learned from many years of system development, this book offers an excellent resource for researchers and postgraduate students interested in CIE development for all multi-disciplinary and interdisciplinary work environments.
Guides readers through the development of geometry and basic proof writing using a historical approach to the topic
In an effort to fully appreciate the logic and structure of geometric proofs, Revolutions of Geometry places proofs into the context of geometry's history, helping readers to understand that proof writing is crucial to the job of a mathematician. Written for students and educators of mathematics alike, the book guides readers through the rich history and influential works, from ancient times to the present, behind the development of geometry. As a result, readers are successfully equipped with the necessary logic to develop a full understanding of geometric theorems.
Following a presentation of the geometry of ancient Egypt, Babylon, and China, the author addresses mathematical philosophy and logic within the context of works by Thales, Plato, and Aristotle. Next, the mathematics of the classical Greeks is discussed, incorporating the teachings of Pythagoras and his followers along with an overview of lower-level geometry using Euclid's Elements. Subsequent chapters explore the work of Archimedes, Viete's revolutionary contributions to algebra, Descartes' merging of algebra and geometry to solve the Pappus problem, and Desargues' development of projective geometry. The author also supplies an excursion into non-Euclidean geometry, including the three hypotheses of Saccheri and Lambert and the near simultaneous discoveries of Lobachevski and Bolyai. Finally, modern geometry is addressed within the study of manifolds and elliptic geometry inspired by Riemann's work, Poncelet's return to projective geometry, and Klein's use of group theory to characterize different geometries.
The book promotes the belief that in order to learn how to write proofs, one needs to read finished proofs, studying both their logic and grammar.?Each chapter features a concise introduction to the presented topic, and chapter sections conclude with exercises that are designed to reinforce the material and provide readers with ample practice in writing proofs. In addition, the overall presentation of topics in the book is in chronological order, helping readers appreciate the relevance of geometry within the historical development of mathematics.?
Well organized and clearly written, Revolutions of Geometry is a valuable book for courses on modern geometry and the history of mathematics at the upper-undergraduate level. It is also a valuable reference for educators in the field of mathematics.
A one-of-a-kind compilation of modern statistical methods designed to support and advance research across the social sciences
Statistics in the Social Sciences: Current Methodological Developments presents new and exciting statistical methodologies to help advance research and data analysis across the many disciplines in the social sciences. Quantitative methods in various subfields, from psychology to economics, are under demand for constant development and refinement. This volume features invited overview papers, as well as original research presented at the Sixth Annual Winemiller Conference: Methodological Developments of Statistics in the Social Sciences, an international meeting that focused on fostering collaboration among mathematical statisticians and social science researchers.
The book provides an accessible and insightful look at modern approaches to identi-fying and describing current, effective methodologies that ultimately add value to various fields of social science research. With contributions from leading international experts on the topic, the book features in-depth coverage of modern quantitative social sciences topics, including:
Correlation Structures
Structural Equation Models and Recent Extensions
Order-Constrained Proximity Matrix Representations
Multi-objective and Multi-dimensional Scaling
Differences in Bayesian and Non-Bayesian Inference
Bootstrap Test of Shape Invariance across Distributions
Statistical Software for the Social Sciences
Statistics in the Social Sciences: Current Methodological Developments is an excellent supplement for graduate courses on social science statistics in both statistics departments and quantitative social sciences programs. It is also a valuable reference for researchers and practitioners in the fields of psychology, sociology, economics, and market research.
The work begins with an overview of the structure of the GAMS language, and discusses issues relating to the management of data in GAMS models. The authors provide models for mean-variance portfolio optimization which address the question of trading off the portfolio expected return against its risk. Fixed income portfolio optimization models perform standard calculations and allow the user to bootstrap a yield curve from bond prices. Dedication models allow for standard portfolio dedication with borrowing and re-investment decisions, and are extended to deal with maximisation of horizon return and to incorporate various practical considerations on the portfolio tradeability. Immunization models provide for the factor immunization of portfolios of treasury and corporate bonds.
The scenario-based portfolio optimization problem is addressed with mean absolute deviation models, tracking models, regret models, conditional VaR models, expected utility maximization models and put/call efficient frontier models. The authors employ stochastic programming for dynamic portfolio optimization, developing stochastic dedication models as stochastic extensions of the fixed income models discussed in chapter 4. Two-stage and multi-stage stochastic programs extend the scenario models analysed in Chapter 5 to allow dynamic rebalancing of portfolios as time evolves and new information becomes known. Models for structuring index funds and hedging interest rate risk on international portfolios are also provided.
The final chapter provides a set of ‘case studies’: models for large-scale applications of portfolio optimization, which can be used as the basis for the development of business support systems to suit any special requirements, including models for the management of participating insurance policies and personal asset allocation.
The title will be a valuable guide for quantitative developers and analysts, portfolio and asset managers, investment strategists and advanced students of finance.
In the space of 10 minutes, how do you confidently assess your patient’s condition and make an accurate diagnosis?
This concise guide provides a systematic way of collecting the essential clinical information swiftly and effectively.
The individual disease sections are uniformly structured to provide:
· Key features of the history, including questions relevant to patients and important for making a diagnosis
· The ‘value’ of present or absent symptoms for diagnosis and prognosis
· What should be examined and why
· A summary of ‘red flags’ – issues that must be assessed
· Important differential diagnoses and their clinical features
· Useful tips, tricks and hints for effective patient assessment
Every health professional, who has to assess patients under time constraints, as well as advanced medical students preparing for final exams, will find this new, easily accessible and comprehensive guide invaluable
“Being responsible for dealing with most of the health problems of most of the population most of the time is quite a challenge… Both students and doctors, and not just those at the start of their careers, will benefit from reading this beautifully structured book which will help them get the very best out of clearly focused consultations. Combined with the vital attributes of listening and caring, using the knowledge and support this book provides will help us all become more effective doctors.” - Professor David Haslam, CBE, FRCP, FFPH, FRCGP, Past President of the Royal College of General Practitioners, London, UK
Apply adaptive research to improve results in drug development
The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently.
With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development.
Chapters explore such subjects as:
The adaptive concept
Design and operational adaptations
Sample-size reestimation
Agile clinical development
Safety and dose finding
Statistics in adaptive research, including frequentist and Bayesian approaches
Data management technologies
The future of clinical development
By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.
As with previous editions, the first part of the book is devoted to the mechanisms of tumour development and cancer treatment. This is followed by a systematic account of the current management of individual major cancers. For each tumour there are details of the pathology, mode of spread, clinical presentation, staging and treatment with radiotherapy and chemotherapy.
This accessible and practical resource will be invaluable to trainees in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and professions allied to medicine.
The second edition of Environmental Health: From Global to Local, a comprehensive introductory text, offers an overview of the methodology and paradigms of this burgeoning field, ranging from ecology to epidemiology, from toxicology to environmental psychology, and from genetics to
ethics. Expert contributors discuss the major issues in contemporary environmental health: air,
water, food safety, occupational health, radiation, chemical and physical hazards, vector control, and injuries. Also emphasizing a wide variety of issues of global interest, the thoroughly revised second edition contains updated information on such timely topics as toxicology, exposure assessment,
climate change, population pressure, developing nations and urbanization, energy production, building and community design, solid and hazardous waste, and disaster preparedness. In addition, each chapter of Environmental Health includes learning objectives, key points, and discussion questions.
Praise for the first edition of Environmental Health
"A classic textbook for the dynamic, evolving field of environmental health, thoughtful, well written, well balanced and referenced. An excellent overview of a multifaceted approach to environmental health."— AOEC Newsletter (Association of Occupational and Environmental Clinics)
"With its many examples, clear explanations, and emphasis on big picture themes and relevance, it is an astonishingly interesting read."—Global Public Health
"The book's chapters contain highly pertinent insights and information on environmental issues that go beyond the usual boundaries of classic environmental health."—Environmental Health Perspectives
Winner, AAP Award for Excellence in Professional and Scholarly Publishing
This book provides an in-depth introduction to existential psychotherapy. Presenting a philosophical alternative to other forms of psychological treatment, it emphasises the problems of living and the human dilemmas that are often neglected by practitioners who focus on personal psychopathology.
Emmy van Deurzen defines the philosophical ideas that underpin existential psychotherapy, summarising the contributions made by Kierkegaard, Nietzsche, Heidegger and Sartre among others. She proposes a systemic and practical method of existential psychotherapy, illustrated with detailed case material. This expanded and updated second edition includes new chapters on the contributions of Max Scheler, Albert Camus, Gabriel Marcel and Emmanuel Levinas, as well as on feminist contributors such as Simone de Beauvoir and Hannah Arendt. In addition a new extended case discussion illustrates the approach in practice.
Everyday Mysteries offers a fresh perspective for anyone training in psychotherapy, counselling, psychology or psychiatry. Those already established in practice will find this a stimulating source of ideas about everyday life and the mysteries of human experience, which will throw new light on old issues.
This book calls for a more nuanced understanding of the nature of the current global health crisis and the political dilemmas faced by those responsible for the development and implementation of responses to it. By charting these debates and showing how they shape the way actors think about key issues relating to health, such as people movement; infectious disease; the business of health; and the consequences of war; this volume provides an innovative and comprehensive introduction to health and international relations for students of global politics, health studies and related disciplines.
Completely revised and updated-Jack Challem's powerful plan to safely prevent and overcome inflammatory disorders
Inflammation is what happens when our body's own defenses turn on us-and it is a huge and growing problem. Written by the author of the groundbreaking Syndrome X, this essential updated edition of The Inflammation Syndrome draws on cutting-edge research conducted around the world to provide a revolutionary approach to healing inflammation-related problems through an easy-to-follow nutrition and supplement program.
Read The Inflammation Syndrome and learn just how easy it can be to take charge of your diet and health.
Ideal for medical students, Foundation Programme doctors and those training in the allied health professions, Medicine at a Glance presents each topic as clear, double-page spreads with key facts accompanied by tables, illustrations, photographs and diagrams.
For more information on the complete range of Wiley-Blackwell medical student and junior doctor publishing, please visit: www.wileymedicaleducation.com
Reviews of previous editions
'Fantastic revision tool before finals with all the breadth of information you need and full colour, clearly laid out diagrams.’
Medical Student, St. Georges Medical School
‘The most up-to-date and best presented clinical medicine text on the market. It contains succinct and clear explanations of the medical conditions any student is expected to know. A student favourite.’
Medical Student, Nottingham University
‘I definitely recommend this book to all final year students…’
Final Year Student, GKT
‘...once you start using this book, you won’t say goodbye to it...’
Gube Magazine, Melbourne University Medical Students Association